产品货号：
Z38374
中文名称：
TrkB/NTRK2抗体
英文名称：
Anti-TrkB/NTRK2 Antibody (Clone#1446CT494.85.83.49)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TrkB/NTRK2 Antibody (Clone#1446CT494.85.83.49) |
| 指标别名 | GP145 TrkB;NTRK2;TrkB;TrkB tyrosine kinase |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,FCM,IHC |
| 基因名称 | NTRK2 |
| 克隆号 | 1446CT494.85.83.49 |
| 抗体来源 | Mouse |
| 免疫原 | This NTRK2 antibody is generated from a mouse immunized with a recombinant protein. |
| 计算分子量 | 92kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival,proliferation,migration,differentiation,and synapse formation and plasticity.Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin- 4.Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2.Upon ligand-binding,undergoes homodimerization,autophosphorylation and activation.Recruits,phosphorylates and/or activates several downstream effectors including SHC1,FRS2,SH2B1,SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades.Through SHC1,FRS2,SH2B1,SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth.Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival.Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity.Thereby,plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation.PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival.Hence,it is able to suppress anoikis,the apoptosis resulting from loss of cell-matrix interactions.May also play a role in neutrophin- dependent calcium signaling in glial cells and mediate communication between neurons and glia. |
| Uniprot ID | Q16620 |
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